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You can find more treatment details in Treatment for Triple-negative Breast Cancer. Local or regional treatments for stage IV breast cancer Although systemic drugs are the main treatment for stage IV breast cancer, local and regional treatments such as surgery, radiation therapy, or regional chemotherapy are sometimes used as well. Oct 13, 2025 · Treatments for Metastatic Breast Cancer Metastatic breast cancer (also called stage IV or advanced breast cancer) is breast cancer that has spread beyond the breast and nearby lymph nodes to other parts of the body (most often the bones, lungs, liver or brain). Metastatic breast cancer cannot be cured today. However, it can be treated. Treatment focuses on extending life and maintaining Metastatic Breast Cancer Metastatic breast cancer (advanced breast cancer or Stage IV breast cancer) is cancer that’s spread from your breast to other areas of your body. There isn’t a cure, but thanks to newer treatments, more people with metastatic breast cancer are living longer than ever before. Abstract In the last years we have witnessed tremendous advancements in the treatment landscape of metastatic breast cancer (MBC), leading to a progressive prolongation of progression-free survival and, in some cases, also of overall survival. This led to a substantial increase of advanced disease treatability. Apr 16, 2025 · Stage 4 breast cancer is advanced breast cancer that has metastasized, or spread, from the original location in the breast to other organs of the body, such as the bones, lungs, liver, or brain. Stage 4 breast cancer is also called metastatic breast cancer or breast cancer recurrence. Even though Stage 4 breast cancer is found in other areas of the body, it is still considered breast cancer Data on CDK4/6i sequencing from these 3 studies will further impact the fast-evolving treatment landscape of ER+/HER2− mBC. In the phase III PADA-1 study, patients with ER+/HER2– mBC and no prior systemic anticancer therapy for

advanced or metastatic disease received AI plus palbociclib, with monitoring for ESR1 mutation. 6 What can you do to get the best care? Metastatic breast cancer (MBC) is breast cancer that has spread to other parts of the body. Metastatic breast cancer is also called advanced breast cancer. In the U.S. today, there are an estimated 200,000 women living with metastatic breast cancer, also called stage 4 breast cancer or advanced breast cancer. In addition, one in three breast cancer survivors will be diagnosed with a recurrence (cancer that has come back after a diagnosis and treatment), which can present itself in other organs of the body and metastasize. Alarmingly, in recent Oct 1, 2025 · Doctors usually treat metastatic breast cancer in any part of the body with systemic medicines, which treat cancer throughout the entire body. Chemotherapy, hormonal therapy, targeted therapies, and immunotherapy are all systemic medications. Local treatments that target a specific part of the body, such as surgery or radiation, are sometimes recommended. Feb 7, 2025 · INTRODUCTION Although metastatic breast cancer (MBC) is unlikely to be cured, meaningful improvements in survival have been seen, coincident with the introduction of newer systemic therapies [1-3]. Median overall survival among patients with metastatic breast cancer now is slightly over three years, with a range from a few months to many years [4]. The selection of a therapeutic strategy